1. The priming event on the lagging strand establishes a replication fork . 2. Human PrimPol ( ccdc111 and in restarting stalled replication forks . 3. Topoisomerases are responsible for removing these supercoils ahead of the replication fork . 4. Primosomes are nucleoproteins assemblies that activate DNA replication forks . 5. DNA damage prevents the normal enzymatic synthesis of DNA by the replication fork . 6. All other proteins at the replication fork are linked directly or indirectly to DnaB. 7. The DNA helicases and polymerases must remain in close contact at the replication fork . 8. Termination requires that the progress of the DNA replication fork must stop or be blocked. 9. Gyrase is most commonly found upstream of the replication fork , where the supercoils form. 10. Spatial juxtaposition of replication sites brings "'clustering "'of replication forks .
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